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Discovery of a Chemical Modification by Citric Acid in a Recombinant Monoclonal Antibody
[Image: see text] Recombinant therapeutic monoclonal antibodies exhibit a high degree of heterogeneity that can arise from various post-translational modifications. The formulation for a protein product is to maintain a specific pH and to minimize further modifications. Generally Recognized as Safe...
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| Main Authors: | , , , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American
Chemical
Society
2014
|
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4165448/ https://ncbi.nlm.nih.gov/pubmed/25136741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac502179m |
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