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Discovery of a Chemical Modification by Citric Acid in a Recombinant Monoclonal Antibody

[Image: see text] Recombinant therapeutic monoclonal antibodies exhibit a high degree of heterogeneity that can arise from various post-translational modifications. The formulation for a protein product is to maintain a specific pH and to minimize further modifications. Generally Recognized as Safe...

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Библиографические подробности
Главные авторы: Chumsae, Chris, Zhou, Liqiang Lisa, Shen, Yang, Wohlgemuth, Jessica, Fung, Emma, Burton, Randall, Radziejewski, Czeslaw, Zhou, Zhaohui Sunny
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2014
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165448/
https://ncbi.nlm.nih.gov/pubmed/25136741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac502179m
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