Intronic miR-3151 Within BAALC Drives Leukemogenesis by Deregulating the TP53 Pathway

The BAALC/miR-3151 locus on chromosome 8q22 contains both the BAALC gene (for brain and acute leukemia, cytoplasmic) and miR-3151, which is located in intron 1 of BAALC. Older acute myeloid leukemia (AML) patients with high expression of both miR-3151 and the BAALC mRNA transcript have a low surviva...

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Main Authors: Eisfeld, Ann-Kathrin, Schwind, Sebastian, Patel, Ravi, Huang, Xiaomeng, Santhanam, Ramasamy, Walker, Christopher J., Markowitz, Joseph, Hoag, Kevin W., Jarvinen, Tiina M., Leffel, Benjamin, Perrotti, Danilo, Carson, William E., Marcucci, Guido, Bloomfield, Clara D., de la Chapelle, Albert
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165404/
https://ncbi.nlm.nih.gov/pubmed/24736457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004762
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