Therapeutic Targeting of Src Kinase in Myofibroblast Differentiation and Pulmonary Fibrosis

Myofibroblasts are effector cells in fibrotic disorders that synthesize and remodel the extracellular matrix (ECM). This study investigated the role of the Src kinase pathway in myofibroblast activation in vitro and fibrogenesis in vivo. The profibrotic cytokine, transforming growth factor β1 (TGF-β...

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Main Authors: Hu, Meng, Che, Pulin, Han, Xiaosi, Cai, Guo-Qiang, Liu, Gang, Antony, Veena, Luckhardt, Tracy, Siegal, Gene P., Zhou, Yong, Liu, Rui-ming, Desai, Leena P., O’Reilly, Philip J., Thannickal, Victor J., Ding, Qiang
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2014
Ábhair:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165028/
https://ncbi.nlm.nih.gov/pubmed/25047515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.216044
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