Therapeutic Targeting of Src Kinase in Myofibroblast Differentiation and Pulmonary Fibrosis

Myofibroblasts are effector cells in fibrotic disorders that synthesize and remodel the extracellular matrix (ECM). This study investigated the role of the Src kinase pathway in myofibroblast activation in vitro and fibrogenesis in vivo. The profibrotic cytokine, transforming growth factor β1 (TGF-β...

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Detalhes bibliográficos
Main Authors: Hu, Meng, Che, Pulin, Han, Xiaosi, Cai, Guo-Qiang, Liu, Gang, Antony, Veena, Luckhardt, Tracy, Siegal, Gene P., Zhou, Yong, Liu, Rui-ming, Desai, Leena P., O’Reilly, Philip J., Thannickal, Victor J., Ding, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165028/
https://ncbi.nlm.nih.gov/pubmed/25047515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.216044
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