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Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

Matrix stiffening and myofibroblast resistance to apoptosis are cardinal features of chronic fibrotic diseases involving diverse organ systems. The interactions between altered tissue biomechanics and cellular signaling that sustain progressive fibrosis are not well defined. In this study, we used e...

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Main Authors: Zhou, Yong, Huang, Xiangwei, Hecker, Louise, Kurundkar, Deepali, Kurundkar, Ashish, Liu, Hui, Jin, Tong-Huan, Desai, Leena, Bernard, Karen, Thannickal, Victor J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582144/
https://ncbi.nlm.nih.gov/pubmed/23434591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66700
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