Therapeutic Targeting of Src Kinase in Myofibroblast Differentiation and Pulmonary Fibrosis

Myofibroblasts are effector cells in fibrotic disorders that synthesize and remodel the extracellular matrix (ECM). This study investigated the role of the Src kinase pathway in myofibroblast activation in vitro and fibrogenesis in vivo. The profibrotic cytokine, transforming growth factor β1 (TGF-β...

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Bibliografiska uppgifter
Huvudupphovsmän: Hu, Meng, Che, Pulin, Han, Xiaosi, Cai, Guo-Qiang, Liu, Gang, Antony, Veena, Luckhardt, Tracy, Siegal, Gene P., Zhou, Yong, Liu, Rui-ming, Desai, Leena P., O’Reilly, Philip J., Thannickal, Victor J., Ding, Qiang
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Pharmacology and Experimental Therapeutics 2014
Ämnen:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165028/
https://ncbi.nlm.nih.gov/pubmed/25047515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.216044
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