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Serpine 1 induces alveolar type II cell senescence through activating p53‐p21‐Rb pathway in fibrotic lung disease

Senescence of alveolar type 2 (ATII) cells, progenitors of the alveolar epithelium, is implicated in the pathogeneses of idiopathic pulmonary fibrosis (IPF), an aging‐related progressive fatal lung disorder with unknown etiology. The mechanism underlying ATII cell senescence in fibrotic lung disease...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Jiang, Chunsun, Liu, Gang, Luckhardt, Tracy, Antony, Veena, Zhou, Yong, Carter, A. Brent, Thannickal, Victor J., Liu, Rui‐Ming
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595683/
https://ncbi.nlm.nih.gov/pubmed/28722352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12643
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