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Dopamine D(1) Receptor Signaling: Does Gα(Q)–Phospholipase C Actually Play a Role?
Despite numerous studies showing therapeutic potential, no central dopamine D(1) receptor ligand has ever been approved, because of potential limitations, such as hypotension, seizures, and tolerance. Functional selectivity has been widely recognized as providing a potential mechanism to develop nov...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4165024/ https://ncbi.nlm.nih.gov/pubmed/25052835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.214411 |
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