Dopamine D(1) Receptor Signaling: Does Gα(Q)–Phospholipase C Actually Play a Role?

Despite numerous studies showing therapeutic potential, no central dopamine D(1) receptor ligand has ever been approved, because of potential limitations, such as hypotension, seizures, and tolerance. Functional selectivity has been widely recognized as providing a potential mechanism to develop nov...

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Bibliographic Details
Main Authors: Lee, Sang-Min, Yang, Yang, Mailman, Richard B.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165024/
https://ncbi.nlm.nih.gov/pubmed/25052835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.214411
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