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Dopamine D(1) Receptor Signaling: Does Gα(Q)–Phospholipase C Actually Play a Role?
Despite numerous studies showing therapeutic potential, no central dopamine D(1) receptor ligand has ever been approved, because of potential limitations, such as hypotension, seizures, and tolerance. Functional selectivity has been widely recognized as providing a potential mechanism to develop nov...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4165024/ https://ncbi.nlm.nih.gov/pubmed/25052835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.214411 |
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