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Pancreatic β-Cell–specific Ablation of TASK-1 Channels Augments Glucose-stimulated Calcium Entry and Insulin Secretion, Improving Glucose Tolerance

Calcium entry through voltage-dependent Ca(2+) channels (VDCCs) is required for pancreatic β-cell insulin secretion. The 2-pore-domain acid-sensitive potassium channel (TASK-1) regulates neuronal excitability and VDCC activation by hyperpolarizing the plasma membrane potential (Δψp); however, a role...

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Main Authors: Dadi, Prasanna K., Vierra, Nicholas C., Jacobson, David A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Endocrine Society 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164933/
https://ncbi.nlm.nih.gov/pubmed/24932805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-2051
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