Inhibition of Pancreatic β-Cell Ca(2+)/Calmodulin-dependent Protein Kinase II Reduces Glucose-stimulated Calcium Influx and Insulin Secretion, Impairing Glucose Tolerance

Glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells is caused by Ca(2+) entry via voltage-dependent Ca(2+) channels. CaMKII is a key mediator and feedback regulator of Ca(2+) signaling in many tissues, but its role in β-cells is poorly understood, especially in vivo. Here, we report...

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Detalhes bibliográficos
Main Authors: Dadi, Prasanna K., Vierra, Nicholas C., Ustione, Alessandro, Piston, David W., Colbran, Roger J., Jacobson, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007438/
https://ncbi.nlm.nih.gov/pubmed/24627477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.562587
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