Glucose-mediated inhibition of calcium-activated potassium channels limits α-cell calcium influx and glucagon secretion

Pancreatic α-cells exhibit oscillations in cytosolic Ca(2+) (Ca(2+)(c)), which control pulsatile glucagon (GCG) secretion. However, the mechanisms that modulate α-cell Ca(2+)(c) oscillations have not been elucidated. As β-cell Ca(2+)(c) oscillations are regulated in part by Ca(2+)-activated K(+) (K(...

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Vydáno v:Am J Physiol Endocrinol Metab
Hlavní autoři: Dickerson, Matthew T., Dadi, Prasanna K., Altman, Molly K., Verlage, Kenneth R., Thorson, Ariel S., Jordan, Kelli L., Vierra, Nicholas C., Amarnath, Gautami, Jacobson, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482666/
https://ncbi.nlm.nih.gov/pubmed/30694690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00342.2018
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