PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis

Bile acids play a pivotal role in the pathological development of inflammatory bowel disease (IBD). However, the mechanism of bile acid dysregulation in IBD remains unanswered. Here we show that intestinal peroxisome proliferator-activated receptor α (PPARα)-UDP-glucuronosyltransferases (UGTs) signa...

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Hlavní autoři: Zhou, Xueyan, Cao, Lijuan, Jiang, Changtao, Xie, Yang, Cheng, Xuefang, Krausz, Kristopher W., Qi, Yunpeng, Sun, Lu, Shah, Yatrik M., Gonzalez, Frank J., Wang, Guangji, Hao, Haiping
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164778/
https://ncbi.nlm.nih.gov/pubmed/25183423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5573
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