Novel role of PKR in inflammasome activation and HMGB1 release

The inflammasome regulates release of caspase activation-dependent cytokines, including IL-1β, IL-18, and high-mobility group box 1 (HMGB1)(1-5). During the course of studying HMGB1 release mechanisms, we discovered an important role of double-stranded RNA dependent protein kinase (PKR) in inflammas...

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Hlavní autoři: Lu, Ben, Nakamura, Takahisa, Inouye, Karen, Li, Jianhua, Tang, Yiting, Lundbäck, Peter, Valdes-Ferrer, Sergio I, Olofsson, Peder S., Kalb, Thomas, Roth, Jesse, Zou, Yongrui, Erlandsson-Harris, Helena, Yang, Huan, Ting, Jenny P-Y, Wang, Haichao, Andersson, Ulf, Antoine, Daniel J., Chavan, Sangeeta S., Hotamisligil, Gökhan S., Tracey, Kevin J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163918/
https://ncbi.nlm.nih.gov/pubmed/22801494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11290
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