α7 Nicotinic Acetylcholine Receptor Signaling Inhibits Inflammasome Activation by Preventing Mitochondrial DNA Release

The mammalian immune system and the nervous system coevolved under the influence of cellular and environmental stress. Cellular stress is associated with changes in immunity and activation of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome, a key component of innate immunity...

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Detalhes bibliográficos
Principais autores: Lu, Ben, Kwan, Kevin, Levine, Yaakov A, Olofsson, Peder S, Yang, Huan, Li, Jianhua, Joshi, Sonia, Wang, Haichao, Andersson, Ulf, Chavan, Sangeeta S, Tracey, Kevin J
Formato: Artigo
Idioma:Inglês
Publicado em: ScholarOne 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153835/
https://ncbi.nlm.nih.gov/pubmed/24849809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2013.00117
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