The Second Sodium Site in the Dopamine Transporter Controls Cation Permeation and Is Regulated by Chloride

The dopamine transporter (DAT) belongs to the family of neurotransmitter:sodium symporters and controls dopamine (DA) homeostasis by mediating Na(+)- and Cl(−)-dependent reuptake of DA. Here we used two-electrode voltage clamp measurements in Xenopus oocytes together with targeted mutagenesis to inv...

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Bibliografiske detaljer
Main Authors: Borre, Lars, Andreassen, Thorvald F., Shi, Lei, Weinstein, Harel, Gether, Ulrik
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162178/
https://ncbi.nlm.nih.gov/pubmed/25063810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.574269
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