Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo

Overexpression of HOXB4 in hematopoietic stem cells (HSCs) leads to increased self-renewal without causing hematopoietic malignancies in transplanted mice. The molecular basis of HOXB4-mediated benign HSC expansion in vivo is not well understood. To gain further insight into the molecular events und...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Yu, Hui, Neale, Geoffrey, Zhang, Hui, Lee, Han M., Ma, Zhijun, Zhou, Sheng, Forget, Bernard G., Sorrentino, Brian P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162106/
https://ncbi.nlm.nih.gov/pubmed/25082879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-10-534735
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados