Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo

Overexpression of HOXB4 in hematopoietic stem cells (HSCs) leads to increased self-renewal without causing hematopoietic malignancies in transplanted mice. The molecular basis of HOXB4-mediated benign HSC expansion in vivo is not well understood. To gain further insight into the molecular events und...

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Bibliographic Details
Main Authors: Yu, Hui, Neale, Geoffrey, Zhang, Hui, Lee, Han M., Ma, Zhijun, Zhou, Sheng, Forget, Bernard G., Sorrentino, Brian P.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2014
Subjects:
Hematopoiesis and Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162106/
https://ncbi.nlm.nih.gov/pubmed/25082879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-10-534735
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