Murine AKAP7 Has a 2′,5′-Phosphodiesterase Domain That Can Complement an Inactive Murine Coronavirus ns2 Gene

Viral 2′,5′-phosphodiesterases (2′,5′-PDEs) help disparate RNA viruses evade the antiviral activity of interferon (IFN) by degrading 2′,5′-oligoadenylate (2-5A) activators of RNase L. A kinase anchoring proteins (AKAPs) bind the regulatory subunits of protein kinase A (PKA) to localize and organize...

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Autors principals: Gusho, Elona, Zhang, Rong, Jha, Babal K., Thornbrough, Joshua M., Dong, Beihua, Gaughan, Christina, Elliott, Ruth, Weiss, Susan R., Silverman, Robert H.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Microbiology 2014
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161237/
https://ncbi.nlm.nih.gov/pubmed/24987090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01312-14
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