Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation

Prior studies have demonstrated that the mouse hepatitis virus (MHV) A59 strain ns2 protein is a member of the 2H phosphoesterase family and exhibits 2′,5′-phosphodiesterase (PDE) activity. During the IFN antiviral response, ns2 cleaves 2′,5′-oligoadenylate (2-5A), a key mediator of RNase L activati...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Gen Virol
Auteurs principaux: Sui, Baokun, Huang, Junhua, Jha, Babal K., Yin, Ping, Zhou, Ming, Fu, Zhen F., Silverman, Robert H., Weiss, Susan R., Peng, Guiqing, Zhao, Ling
Format: Artigo
Langue:Inglês
Publié: Microbiology Society 2016
Sujets:
Short Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974288/
https://ncbi.nlm.nih.gov/pubmed/26757803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jgv.0.000395
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