Homologous 2′,5′-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity

Efficient and productive virus infection often requires viral countermeasures that block innate immunity. The IFN-inducible 2′,5′-oligoadenylate (2-5A) synthetases (OASs) and ribonuclease (RNase) L are components of a potent host antiviral pathway. We previously showed that murine coronavirus (MHV)...

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Bibliografiske detaljer
Main Authors: Zhang, Rong, Jha, Babal K., Ogden, Kristen M., Dong, Beihua, Zhao, Ling, Elliott, Ruth, Patton, John T., Silverman, Robert H., Weiss, Susan R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740845/
https://ncbi.nlm.nih.gov/pubmed/23878220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1306917110
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