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Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold
TASK-1 is a two-pore domain potassium channel that is important to modulating cell excitability, most notably in the context of neuronal pathways. In order to leverage TASK-1 for therapeutic benefit, its physiological role needs better characterization; however, designing selective inhibitors that a...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4160056/ https://ncbi.nlm.nih.gov/pubmed/25017033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.06.032 |
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