Bis[3,5-bis(benzylidene)-4-oxo-1-piperidinyl]amides: A Novel Class of Potent Cytotoxins

The principal objective of this study was the examination of the theory of cytotoxic synergism. In this exploratory study, we tested the hypothesis that doubling the number of sites available for thiol alkylation in a series of candidate cytotoxins increases potency more than two-fold. This concept...

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Detalhes bibliográficos
Main Authors: Das, Swagatika, Das, Umashankar, Varela-Ramírez, Armando, Lema, Carolina, Aguilera, Renato J., Balzarini, Jan, De Clercq, Erik, Dimmock, Stephen G., Gorecki, Dennis K. J., Dimmock, Jonathan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344817/
https://ncbi.nlm.nih.gov/pubmed/21826795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201100199
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