Novel 3,5-bis(arylidene)-4-oxo-1-piperidinyl dimers: Structure—activity relationships and potent antileukemic and antilymphoma cytotoxicity

Novel clusters of 3,5-bis(benzylidene)-4-oxo-1-piperidinyl dimers 3–5 were evaluated against human Molt4/C8 and CEM T-lymphocytes and human HeLa cervix adenocarcinoma cells as well as murine L1210 leukemia neoplasms. Several of these compounds demonstrated IC(50) values in the submicromolar and low...

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Detalhes bibliográficos
Main Authors: Santiago-Vazquez, Yahaira, Das, Swagatika, Das, Umashankar, Robles-Escajeda, Elisa, Ortega, Nora M., Lema, Carolina, Varela-Ramírez, Armando, Aguilera, Renato J., Balzarini, Jan, De Clercq, Erik, Dimmock, Stephen G., Gorecki, Dennis K.J., Dimmock, Jonathan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215945/
https://ncbi.nlm.nih.gov/pubmed/24657568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.03.009
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