Deletion of FoxO1 Leads to Shortening of QRS by Increasing Na(+) Channel Activity through Enhanced Expression of both Cardiac Na(V)1.5 and β3 Subunit

Our in vitro studies revealed that a transcription factor, Forkhead box protein O1 (FoxO1), negatively regulates the expression of Na(V)1.5, a main α subunit of the cardiac Na(+) channel, by altering the promoter activity of SCN5a in HL-1 cardiomyocytes. The in vivo role of FoxO1 in the regulation o...

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Hlavní autoři: Cai, Benzhi, Wang, Ning, Mao, Weike, You, Tao, Lu, Yan, Li, Xiang, Ye, Bo, Li, Faqian, Xu, Haodong
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158923/
https://ncbi.nlm.nih.gov/pubmed/24956219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.06.006
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