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Deletion of FoxO1 Leads to Shortening of QRS by Increasing Na(+) Channel Activity through Enhanced Expression of both Cardiac Na(V)1.5 and β3 Subunit
Our in vitro studies revealed that a transcription factor, Forkhead box protein O1 (FoxO1), negatively regulates the expression of Na(V)1.5, a main α subunit of the cardiac Na(+) channel, by altering the promoter activity of SCN5a in HL-1 cardiomyocytes. The in vivo role of FoxO1 in the regulation o...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4158923/ https://ncbi.nlm.nih.gov/pubmed/24956219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.06.006 |
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