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HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy

The Forkhead box O (FoxO) transcription factors are activated, and necessary for the muscle atrophy, in several pathophysiological conditions, including muscle disuse and cancer cachexia. However, the mechanisms that lead to FoxO activation are not well defined. Recent data from our laboratory and o...

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Библиографические подробности
Главные авторы: Beharry, Adam W., Sandesara, Pooja B., Roberts, Brandon M., Ferreira, Leonardo F., Senf, Sarah M., Judge, Andrew R.
Формат: Artigo
Язык:Inglês
Опубликовано: The Company of Biologists 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970557/
https://ncbi.nlm.nih.gov/pubmed/24463822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.136390
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