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HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy

The Forkhead box O (FoxO) transcription factors are activated, and necessary for the muscle atrophy, in several pathophysiological conditions, including muscle disuse and cancer cachexia. However, the mechanisms that lead to FoxO activation are not well defined. Recent data from our laboratory and o...

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Autori principali: Beharry, Adam W., Sandesara, Pooja B., Roberts, Brandon M., Ferreira, Leonardo F., Senf, Sarah M., Judge, Andrew R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970557/
https://ncbi.nlm.nih.gov/pubmed/24463822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.136390
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