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HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy

The Forkhead box O (FoxO) transcription factors are activated, and necessary for the muscle atrophy, in several pathophysiological conditions, including muscle disuse and cancer cachexia. However, the mechanisms that lead to FoxO activation are not well defined. Recent data from our laboratory and o...

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Autores principales: Beharry, Adam W., Sandesara, Pooja B., Roberts, Brandon M., Ferreira, Leonardo F., Senf, Sarah M., Judge, Andrew R.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970557/
https://ncbi.nlm.nih.gov/pubmed/24463822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.136390
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