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Clonal Evolution in Breast Cancer Revealed by Single Nucleus Genome Sequencing
Sequencing studies of breast tumor cohorts have identified many prevalent mutations, but provide limited insight into the genomic diversity within tumors. Here, we developed a whole-genome and exome single cell sequencing approach called Nuc-Seq that utilizes G2/M nuclei to achieve 91% mean coverage...
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| 主要な著者: | , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4158312/ https://ncbi.nlm.nih.gov/pubmed/25079324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13600 |
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