Clonal Evolution in Breast Cancer Revealed by Single Nucleus Genome Sequencing

Sequencing studies of breast tumor cohorts have identified many prevalent mutations, but provide limited insight into the genomic diversity within tumors. Here, we developed a whole-genome and exome single cell sequencing approach called Nuc-Seq that utilizes G2/M nuclei to achieve 91% mean coverage...

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Detalhes bibliográficos
Main Authors: Wang, Yong, Waters, Jill, Leung, Marco L., Unruh, Anna, Roh, Whijae, Shi, Xiuqing, Chen, Ken, Scheet, Paul, Vattathil, Selina, Liang, Han, Multani, Asha, Zhang, Hong, Zhao, Rui, Michor, Franziska, Meric-Bernstam, Funda, Navin, Nicholas E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158312/
https://ncbi.nlm.nih.gov/pubmed/25079324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13600
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