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Identification of Allelic Imbalance with a Statistical Model for Subtle Genomic Mosaicism

Genetic heterogeneity in a mixed sample of tumor and normal DNA can confound characterization of the tumor genome. Numerous computational methods have been proposed to detect aberrations in DNA samples from tumor and normal tissue mixtures. Most of these require tumor purities to be at least 10–15%....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Xia, Rui, Vattathil, Selina, Scheet, Paul
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148184/
https://ncbi.nlm.nih.gov/pubmed/25166618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003765
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