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Ploidy-Seq: inferring mutational chronology by sequencing polyploid tumor subpopulations
Human cancers are frequently polyploid, containing multiple aneuploid subpopulations that differ in total DNA content. In this study we exploit this property to reconstruct evolutionary histories, by assuming that mutational complexity increases with time. We developed an experimental method called...
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| 出版年: | Genome Med |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4343275/ https://ncbi.nlm.nih.gov/pubmed/25729435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-015-0127-5 |
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