SiCloneFit: Bayesian inference of population structure, genotype, and phylogeny of tumor clones from single-cell genome sequencing data

Accumulation and selection of somatic mutations in a Darwinian framework result in intra-tumor heterogeneity (ITH) that poses significant challenges to the diagnosis and clinical therapy of cancer. Identification of the tumor cell populations (clones) and reconstruction of their evolutionary relatio...

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Bibliographic Details
Published in:Genome Res
Main Authors: Zafar, Hamim, Navin, Nicholas, Chen, Ken, Nakhleh, Luay
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2019
Subjects:
Method
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6836738/
https://ncbi.nlm.nih.gov/pubmed/31628257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.243121.118
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