Origin Licensing Requires ATP Binding and Hydrolysis by the MCM Replicative Helicase

Loading of the six related Minichromosome Maintenance (MCM) proteins as head-to-head double hexamers during DNA replication origin licensing is crucial for ensuring once-per-cell-cycle DNA replication in eukaryotic cells. Assembly of these prereplicative complexes (pre-RCs) requires the Origin Recog...

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Bibliographic Details
Main Authors: Coster, Gideon, Frigola, Jordi, Beuron, Fabienne, Morris, Edward P., Diffley, John F.X.
Format: Artigo
Language:Inglês
Published: Cell Press 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157578/
https://ncbi.nlm.nih.gov/pubmed/25087873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.06.034
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