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ATPase-Dependent Quality Control of DNA Replication Origin Licensing
The regulated loading of the Mcm2-7 DNA helicase into pre-replicative complexes (pre-RCs) at multiple replication origins ensures precise once per cell cycle replication in eukaryotic cells. Origin Recognition Complex (ORC), Cdc6 and Cdt1 load Mcm2-7 into a double hexamer bound around duplex DNA in...
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| Published in: | Nature |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4825857/ https://ncbi.nlm.nih.gov/pubmed/23474987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11920 |
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