Concerted Loading of Mcm2-7 Double Hexamers Around DNA during DNA Replication Origin Licensing

The licensing of eukaryotic DNA replication origins, which ensures once per cell cycle replication, involves the loading of six related minichromosome maintenance proteins (Mcm2-7) into prereplicative complexes (pre-RCs). Mcm2-7 forms the core of the replicative DNA helicase, which is inactive in th...

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Bibliographic Details
Main Authors: Remus, Dirk, Beuron, Fabienne, Tolun, Gökhan, Griffith, Jack D., Morris, Edward P., Diffley, John F.X.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804858/
https://ncbi.nlm.nih.gov/pubmed/19896182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.10.015
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