Requirement for PBAF in Transcriptional Repression and Repair at DNA Breaks in Actively Transcribed Regions of Chromatin

Actively transcribed regions of the genome are vulnerable to genomic instability. Recently, it was discovered that transcription is repressed in response to neighboring DNA double-strand breaks (DSBs). It is not known whether a failure to silence transcription flanking DSBs has any impact on DNA rep...

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Autores principales: Kakarougkas, Andreas, Ismail, Amani, Chambers, Anna L., Riballo, Enriqueta, Herbert, Alex D., Künzel, Julia, Löbrich, Markus, Jeggo, Penny A., Downs, Jessica A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157577/
https://ncbi.nlm.nih.gov/pubmed/25066234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.06.028
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