Requirement for PBAF in Transcriptional Repression and Repair at DNA Breaks in Actively Transcribed Regions of Chromatin

Actively transcribed regions of the genome are vulnerable to genomic instability. Recently, it was discovered that transcription is repressed in response to neighboring DNA double-strand breaks (DSBs). It is not known whether a failure to silence transcription flanking DSBs has any impact on DNA rep...

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Autors principals: Kakarougkas, Andreas, Ismail, Amani, Chambers, Anna L., Riballo, Enriqueta, Herbert, Alex D., Künzel, Julia, Löbrich, Markus, Jeggo, Penny A., Downs, Jessica A.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157577/
https://ncbi.nlm.nih.gov/pubmed/25066234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.06.028
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