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Bioenergetic modulation with dichloroacetate reduces the growth of melanoma cells and potentiates their response to BRAF(V600E) inhibition
BACKGROUND: Advances in melanoma treatment through targeted inhibition of oncogenic BRAF are limited owing to the development of acquired resistance. The involvement of BRAF(V600E) in metabolic reprogramming of melanoma cells provides a rationale for co-targeting metabolism as a therapeutic approach...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4156963/ https://ncbi.nlm.nih.gov/pubmed/25182332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0247-5 |
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