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Inhibition of retinoic acid receptor β signaling confers glycolytic dependence and sensitization to dichloroacetate in melanoma cells

Dysregulation of metabolism during melanoma progression is tightly associated with the acquisition of genetic and epigenetic alterations in regulators of metabolic pathways. Retinoic acid receptor beta (RARβ) is epigenetically silenced in a large proportion of melanomas, but a link between RARβ and...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Abildgaard, Cecilie, Dahl, Christina, Abdul-Al, Ahmad, Christensen, Annette, Guldberg, Per
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663589/
https://ncbi.nlm.nih.gov/pubmed/29137417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20476
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