Functional Analysis of Dishevelled-3 Phosphorylation Identifies Distinct Mechanisms Driven by Casein Kinase 1ϵ and Frizzled5

Dishevelled-3 (Dvl3), a key component of the Wnt signaling pathways, acts downstream of Frizzled (Fzd) receptors and gets heavily phosphorylated in response to pathway activation by Wnt ligands. Casein kinase 1ϵ (CK1ϵ) was identified as the major kinase responsible for Wnt-induced Dvl3 phosphorylati...

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Bibliographische Detailangaben
Hauptverfasser: Bernatík, Ondřej, Šedová, Kateřina, Schille, Carolin, Ganji, Ranjani Sri, Červenka, Igor, Trantírek, Lukáš, Schambony, Alexandra, Zdráhal, Zbyněk, Bryja, Vítězslav
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156093/
https://ncbi.nlm.nih.gov/pubmed/24993822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.590638
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