Phosphorylation and Degradation of Tomosyn-2 De-represses Insulin Secretion

The abundance and functional activity of proteins involved in the formation of the SNARE complex are tightly regulated for efficient exocytosis. Tomosyn proteins are negative regulators of exocytosis. Tomosyn causes an attenuation of insulin secretion by limiting the formation of the SNARE complex....

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Detalhes bibliográficos
Main Authors: Bhatnagar, Sushant, Soni, Mufaddal S., Wrighton, Lindsay S., Hebert, Alexander S., Zhou, Amber S., Paul, Pradyut K., Gregg, Trillian, Rabaglia, Mary E., Keller, Mark P., Coon, Joshua J., Attie, Alan D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155689/
https://ncbi.nlm.nih.gov/pubmed/25002582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.575985
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