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mTOR Complex 2 Targets Akt for Proteasomal Degradation via Phosphorylation at the Hydrophobic Motif

The protein kinase Akt (also known as protein kinase B) is a critical signaling hub downstream of various cellular stimuli such as growth factors that control cell survival, growth, and proliferation. The activity of Akt is tightly regulated, and the aberrant activation of Akt is associated with div...

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Detalhes bibliográficos
Main Authors: Wu, You-Tong, Ouyang, Weiming, Lazorchak, Adam S., Liu, Dou, Shen, Han-Ming, Su, Bing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077620/
https://ncbi.nlm.nih.gov/pubmed/21321111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.219923
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