Laddar...
Small molecule H89 renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitors
The mammalian target of rapamycin (mTOR) is an evolutionarily conserved Ser/Thr kinase that comprises two complexes, termed mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). mTORC1 phosphorylates S6K1 at Thr 389, whereas mTORC2 phosphorylates AKT at Ser 473 to promote cell growth. As the mTOR nam...
Sparad:
| I publikationen: | Biochem J |
|---|---|
| Huvudupphovsmän: | , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Portland Press Ltd.
2020
|
| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7261416/ https://ncbi.nlm.nih.gov/pubmed/32347294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20190958 |
| Taggar: |
Lägg till en tagg
Inga taggar, Lägg till första taggen!
|