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Small molecule H89 renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitors
The mammalian target of rapamycin (mTOR) is an evolutionarily conserved Ser/Thr kinase that comprises two complexes, termed mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). mTORC1 phosphorylates S6K1 at Thr 389, whereas mTORC2 phosphorylates AKT at Ser 473 to promote cell growth. As the mTOR nam...
Guardat en:
| Publicat a: | Biochem J |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Portland Press Ltd.
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7261416/ https://ncbi.nlm.nih.gov/pubmed/32347294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20190958 |
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