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Small molecule H89 renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitors
The mammalian target of rapamycin (mTOR) is an evolutionarily conserved Ser/Thr kinase that comprises two complexes, termed mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). mTORC1 phosphorylates S6K1 at Thr 389, whereas mTORC2 phosphorylates AKT at Ser 473 to promote cell growth. As the mTOR nam...
Shranjeno v:
| izdano v: | Biochem J |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Portland Press Ltd.
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7261416/ https://ncbi.nlm.nih.gov/pubmed/32347294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20190958 |
| Oznake: |
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