Phosphorylation and Degradation of Tomosyn-2 De-represses Insulin Secretion

The abundance and functional activity of proteins involved in the formation of the SNARE complex are tightly regulated for efficient exocytosis. Tomosyn proteins are negative regulators of exocytosis. Tomosyn causes an attenuation of insulin secretion by limiting the formation of the SNARE complex....

Full description

Saved in:
Bibliographic Details
Main Authors: Bhatnagar, Sushant, Soni, Mufaddal S., Wrighton, Lindsay S., Hebert, Alexander S., Zhou, Amber S., Paul, Pradyut K., Gregg, Trillian, Rabaglia, Mary E., Keller, Mark P., Coon, Joshua J., Attie, Alan D.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155689/
https://ncbi.nlm.nih.gov/pubmed/25002582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.575985
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items