Phosphorylation and Degradation of Tomosyn-2 De-represses Insulin Secretion

The abundance and functional activity of proteins involved in the formation of the SNARE complex are tightly regulated for efficient exocytosis. Tomosyn proteins are negative regulators of exocytosis. Tomosyn causes an attenuation of insulin secretion by limiting the formation of the SNARE complex....

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Détails bibliographiques
Auteurs principaux: Bhatnagar, Sushant, Soni, Mufaddal S., Wrighton, Lindsay S., Hebert, Alexander S., Zhou, Amber S., Paul, Pradyut K., Gregg, Trillian, Rabaglia, Mary E., Keller, Mark P., Coon, Joshua J., Attie, Alan D.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2014
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155689/
https://ncbi.nlm.nih.gov/pubmed/25002582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.575985
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