IRAK1 and IRAK4 Promote Phosphorylation, Ubiquitination, and Degradation of MyD88 Adaptor-like (Mal)

Signal transduction by Toll-like receptor 2 (TLR2) and TLR4 requires the adaptors MyD88 and Mal (MyD88 adaptor-like) and serine/threonine kinases, interleukin-1 receptor-associated kinases IRAK1 and IRAK4. We have found that both IRAK1 and IRAK4 can directly phosphorylate Mal. In addition, co-expres...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Dunne, Aisling, Carpenter, Susan, Brikos, Constantinos, Gray, Pearl, Strelow, Astrid, Wesche, Holger, Morrice, Nick, O'Neill, Luke A. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881752/
https://ncbi.nlm.nih.gov/pubmed/20400509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.098137
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky