IRAK1 and IRAK4 Promote Phosphorylation, Ubiquitination, and Degradation of MyD88 Adaptor-like (Mal)

Signal transduction by Toll-like receptor 2 (TLR2) and TLR4 requires the adaptors MyD88 and Mal (MyD88 adaptor-like) and serine/threonine kinases, interleukin-1 receptor-associated kinases IRAK1 and IRAK4. We have found that both IRAK1 and IRAK4 can directly phosphorylate Mal. In addition, co-expres...

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Bibliografiske detaljer
Main Authors: Dunne, Aisling, Carpenter, Susan, Brikos, Constantinos, Gray, Pearl, Strelow, Astrid, Wesche, Holger, Morrice, Nick, O'Neill, Luke A. J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881752/
https://ncbi.nlm.nih.gov/pubmed/20400509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.098137
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